北海道大学病院内科Ⅰ(第一内科)

研究業績

業績

H20 研究業績

原著論文
  1. Kikuchi J, Kinoshita I, Shimizu Y, Oizumi S, Nishimura M, Birrer MJ, Dosaka-Akita H. Simultaneous blockade of AP-1 and phosphatidylinositol 3-kinase pathway in non-small cell lung cancer cells. Br J Cancer 99(12):2013-2019 (2008) PubMedへ
  2. Ikeda D, Sakaue S, Kamigaki M, Ohira H, Itoh N, Ohtsuka Y, Tsujino I, Nishimura M. Knockdown of Macrophage Migration Inhibitory Factor Disrupts Adipogenesis in 3T3-L1 Cells. Endocrinology 149(12):6037-42 (2008) PubMedへ
  3. Suzuki M, Betsuyaku T, Ito Y, Nagai K, Nasuhara Y, Kaga K, Kondo S, Nishimura M. Down-regulated NF-E2-related factor 2 in pulmonary macrophages of aged smokers and patients with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 39(6):673-82 (2008) PubMedへ
  4. Inoue A, Sugawara S, Yamazaki K, Maemondo M, Suzuki T, Gomi K, Takanashi S, Inoue C, Inage M, Yokouchi H, Watanabe H, Tsukamoto T, Saijo Y, Ishimoto O, Hommura F, Nukiwa T. Randomized phase II trial comparing amrubicin with topotecan in patients with previously treated small-cell lung cancer: North Japan Lung Cancer Study Group Trial 0402. J Clin Oncol 26(33):5401-6 (2008) PubMedへ
  5. Nagai K, Betsuyaku T, Konno S, Ito Y, Nasuhara Y, Hizawa N, Kondo T, Nishimura M. Diversity of protein carbonylation in allergic airway inflammation. Free Radic Res 24:1-9 (2008) PubMedへ
  6. Adair-Kirk TL, Atkinson JJ, Griffin GL, Watson MA, Kelley DG, DeMello D, Senior RM, Betsuyaku T. Distal airways in mice exposed to cigarette smoke: Nrf2-regulated genes are increased in Clara cells. Am J Respir Cell Mol Biol 39(4):400-11 (2008) PubMedへ
  7. Kikuchi E, Yamazaki K, Nakayama E, Sato S, Uenaka A, Yamada N, Oizumi S, Dosaka-Akita H, Nishimura M. Prolonged survival of patients with lung adenocarcinoma expressing XAGE-1b and HLA class I antigens. Cancer Immun 8:13 (2008) PubMedへ
  8. Hizawa N, Makita H, Nasuhara Y, Hasegawa M, Nagai K, Ito Y, Betsuyaku T, Konno S, Nishimura M; Hokkaido COPD Cohort Study Group. Functional single nucleotide polymorphisms of the CCL5 gene and nonemphysematous phenotype in COPD patients. Eur Respir J 32(2):372-8 (2008) PubMedへ
  9. Sakaue S, Kamigaki M, Yoshimura H, Nishimura M. Effects of Replacing Metformin with Pioglitazone on Glycemic Control in Japanese Patients with Poorly Controlled Type 2 Diabetes Mellitus: A 12-Week, Open-Label, Prospective Study. Curr Ther Res Clin Exp 69(4) :364-377 (2008)
  10. Kereiakes DJ, Petersen JL, Batchelor WB, Fitzgerald PJ, Mehran R, Lansky A, Tsujino I, Schofer J, Dubois C, Verheye S, Cristea E, Garg J, Wijns W, Krucoff MW. Clinical and angiographic outcomes in diabetic patients following single or multivessel stenting in the COSTAR II randomized trial. J Invasive Cardiol 20(7):335-41 (2008) PubMedへ
  11. Nakagawa K, Yamazaki K, Kunitoh H, Hida T, Gemba K, Shinkai T, Ichinose Y, Adachi S, Nambu Y, Saijo N, Fukuoka M. Efficacy and safety of pemetrexed in combination with cisplatin for malignant pleural mesothelioma: a phase I/II study in Japanese patients. Jpn J Clin Oncol 38(5):339-46 (2008) PubMedへ
  12. Oizumi S, Deyev V, Yamazaki K, Schreiber T, Strbo N, Rosenblatt J, Podack ER. Surmounting tumor-induced immune suppression by frequent vaccination or immunization in the absence of B cells. J Immunother 31(4):394-401 (2008) PubMedへ
  13. Ohira H, Tsujino I, Ishimaru S, Oyama N, Takei T, Tsukamoto E, Miura M, Sakaue S, Tamaki N, Nishimura M. Myocardial imaging with 18F-fluoro-2-deoxyglucose positron emission tomography and magnetic resonance imaging in sarcoidosis. Eur J Nucl Med Mol Imaging 35(5):933-41 (2008) PubMedへ
  14. Hosokawa T, Betsuyaku T, Odajima N, Suzuki M, Mochitate K, Nasuhara Y, Nishimura M. Role of basement membrane in EMMPRIN/CD147 induction in rat tracheal epithelial cells. Biochem Biophys Res Commun 368(2):426-32 (2008) PubMedへ
  15. Nagai K, Betsuyaku T, Suzuki M, Nasuhara Y, Kaga K, Kondo S, Nishimura M. Dual oxidase 1 and 2 expression in airway epithelium of smokers and patients with mild/moderate chronic obstructive pulmonary disease. Antioxid Redox Signal 10(4):705-14 (2008) PubMedへ
  16. Kikuchi E, Yamazaki K, Kikuchi J, Hasegawa N, Hashimoto S, Ishizaka A, Nishimura M. Pharmacokinetics of clarithromycin in bronchial epithelial lining fluid. Respirology 13(2):221-6 (2008) PubMedへ
  17. Shimizu Y, Kinoshita I, Kikuchi J, Yamazaki K, Nishimura M, Birrer MJ, Dosaka-Akita H. Growth inhibition of non-small cell lung cancer cells by AP-1 blockade using a cJun dominant-negative mutant. Br J Cancer 98(5):915-22 (2008) PubMedへ
  18. Suzuki M, Betsuyaku T, Nagai K, Fuke S, Nasuhara Y, Kaga K, Kondo S, Hamamura I, Hata J, Takahashi H, Nishimura M. Decreased airway expression of vascular endothelial growth factor in cigarette smoke-induced emphysema in mice and COPD patients. Inhal Toxicol 20(3):349-59 (2008) PubMedへ
  19. Yokouchi H, Yamazaki K, Chamoto K, Kikuchi E, Shinagawa N, Oizumi S, Hommura F, Nishimura T, Nishimura M. Anti-OX40 monoclonal antibody therapy in combination with radiotherapy results in therapeutic antitumor immunity to murine lung cancer. Cancer Sci 99(2):361-7 (2008) PubMedへ
  20. Onimaru R, Fujino M, Yamazaki K, Onodera Y, Taguchi H, Katoh N, Hommura F, Oizumi S, Nishimura M, Shirato H. Steep dose-response relationship for stage I non-small-cell lung cancer using hypofractionated high-dose irradiation by real-time tumor-tracking radiotherapy. Int J Radiat Oncol Biol Phys 70(2):374-81 (2008) PubMedへ
  21. Imura M, Yamazaki K, Kubota KC, Itoh T, Onimaru R, Cho Y, Hida Y, Kaga K, Onodera Y, Ogura S, Dosaka-Akita H, Shirato H, Nishimura M. Histopathologic consideration of fiducial gold markers inserted for real-time tumor-tracking radiotherapy against lung cancer. Int J Radiat Oncol Biol Phys 70(2):382-4 (2008) PubMedへ
  22. Shinagawa N, Yamazaki K, Tamura Y, Imai A, Kikuchi E, Yokouchi H, Hommura F, Oizumi S, Nishimura M. Immunotherapy with dendritic cells pulsed with tumor-derived gp96 against murine lung cancer is effective through immune response of CD8+ cytotoxic T lymphocytes and natural killer cells. Cancer Immunol Immunother 57(2):165-74 (2008) PubMedへ
  23. Betsuyaku T, Hamamura I, Hata J, Takahashi H, Mitsuhashi H, Adair-Kirk TL, Senior RM, Nishimura M. Bronchiolar chemokine expression is different after single versus repeated cigarette smoke exposure. Respir Res 9:7 (2008) PubMedへ
  24. Miyazawa A, Ako J, Hongo Y, Hur SH, Tsujino I, Courtney BK, Hassan AH, Kandzari DE, Honda Y, Fitzgerald PJ; ENDEAVOR III Investigators. Comparison of vascular response to zotarolimus-eluting stent versus sirolimus-eluting stent: intravascular ultrasound results from ENDEAVOR III. Am Heart J 155(1):108-13 (2008) PubMedへ
  25. 清水健一,檜澤伸之,牧田比呂仁,今野 哲,南須原康行,別役智子,西村正治. 慢性閉塞性肺疾患と中高年発症喫煙者喘息における血清総IgE値,末梢血好酸球数およびアトピー素因の比較. 日本医師会雑誌 137(2):326-331 (2008)
  26. 服部健史,今野 哲,清水薫子,清水健一,伊佐田 朗,高橋 歩,前田由起子,牧田比呂仁,澤崎 健,檜澤伸之,西村正治. アトピー素因の判定に必要なアレルゲン数の検討. アレルギー 57(5):543-551 (2008)
  27. 伊佐田 朗,檜澤伸之,清水健一,清水薫子,高橋 歩,服部健史,前田由起子,高橋大輔,今野 哲,西村正治. β2アドレナリン受容体遺伝子(Arg16Gly)多型が気管支喘息患者のβ2刺激薬長期連用に与える影響. アレルギー 57(6):713-721 (2008)
  28. 清水薫子,今野 哲,清水健一,伊佐田 朗,高橋 歩,服部健史,前田由起子,高橋大輔,高橋 清,中川武正,谷口正実,秋山一男,赤澤 晃,檜澤伸之,西村正治. 北海道上士幌町における成人喘息、アレルギー性鼻炎有病率 -特に喫煙及び肥満との関連について-. アレルギー 57(7):835-842 (2008)
  29. 伊佐田 朗,今野 哲,高橋 歩,服部健史,前田由起子,檜澤伸之,西村正治. 重症持続型喘息患者におけるプロピオン酸フルチカゾン高用量からブデソニド高用量へ変更した際の臨床効果の検討. アレルギー・免疫 15(8):102-109 (2008)
  30. 福居嘉信,檜澤伸之,高橋大輔,前田由起子,小林基子,南須原康行,西村正治. 呼吸器内科医による成人喘息診断の実態 ―アンケート調査の結果―. 日本呼吸器学会雑誌 46(8):601-607 (2008)
  31. 福居嘉信,檜澤伸之,高橋大輔,前田由起子,小林基子,南須原康行,西村正治. 喘息におけるロイコトリエン受容体拮抗薬の有効性とその背景の検討 -アンケート調査の結果-. 日本呼吸器学会雑誌 46(12):972-980 (2008)
症例報告
  1. Suzuki M, Asahina H, Konishi J, Yamazaki K, Nishimura M. Recurrent gefitinib-induced interstitial lung disease. Intern Med. 47(6):533-6 (2008) PubMedへ
  2. Tamura K, Yoshinaga T, Tanino M, Kimura T, Yamada N, Nishimura M, Fukuda S, Nishihara H, Shindoh M, Tanaka S. Hypopharyngeal squamous cell carcinoma producing both granulocyte colony-stimulating factor and parathyroid hormone-related protein. Pathol Int. 58(10):652-6 (2008) PubMedへ
  3. 高橋 歩,今野 哲,服部健史,大野重昭,西村正治. 結核との鑑別が問題となったサルコイドーシスの1例. 日本サルコイドーシス/肉芽腫性疾患学会雑誌 28(1):69-74(2008)
  4. 山田範幸,山崎浩一,品川尚文,柏村正明,西村正治. 重症気道熱傷後に気管・気管支狭窄を合併しバルーン拡張術が有効であった1例. 気管支学 30(4):215-219(2008)
  5. 守山千夏,山崎浩一,横内 浩,菊地英毅,大泉聡史,西村正治. 原発巣の自然退縮中に脳転移が出現した肺大細胞癌の1例. 肺癌 48(2):112-117(2008)
総説・解説・評論等
  1. 今野哲:網羅的遺伝子・蛋白質発現解析による、気管支喘息/アレルギー関連遺伝子・分子の探索,International Review of Asthma,10: 42-51 (2008)
  2. 南須原康行:特集 COPDの予後を左右する合併疾患 多血症・貧血,COPD Frontier,7: 85-88 (2008)
  3. 南須原康行:特集 胸部画像診断のトピックス COPD,呼吸器科,14: 385-390 (2008)
  4. Nishimura M:Application of three-dimensional airway algorithms in a clinical study,Proc Am Thorac Soc,5: 910-914 (2008)
  5. 西村正治:北海道低肺創立二十周年記念医療講演 なぜ人は息切れを感ずるか,北海道低肺,1: 8 (2008)
  6. 西村正治:特集1 酸素を吸って、もっともっと活動的な生活に!,HOT,36: 2-3 (2008)
  7. 西村正治:特集 COPD(慢性閉塞性肺疾患)-病態と治療 COPDの病態と診断・予防・治療 COPDの病態,カレントテラピー,26:8-12 (2008)
  8. 西村正治:慢性閉塞性肺疾患 (COPD) :診断と治療の進歩 I 病因と病態 1. 歴史と概念,日本内科学会雑誌,97:4-10 (2008)
  9. 服部健史,西村正治:精密肺機能検査 ― 残気率と肺拡散能 ―,日本医師会雑誌特別号 生涯教育シリーズ75 呼吸器疾患診療マニュアル,137:127-128 (2008)
  10. 本間行彦,櫻井みち代,大塚吉則,今井純生,八重樫 稔,石川由香子,宮坂史路,百野公平,大塚義紀,棟方 充,南須原康行,西村正治: 特発性間質性肺炎(IIP)の漢方治療,漢方と免疫・アレルギー,22:124-138 (2008)
  11. 牧田比呂仁,西村正治:特集 治療可能な病態COPD-診療の実際と展望 <COPDの診断> COPDの画像診断,内科,101:231-237 (2008)
  12. 牧田比呂仁,西村正治:特集 呼吸器疾患における医師主導臨床試験の取り組みと将来展望 COPD:北海道COPDコホート研究,分子呼吸器病,12: 123-128 (2008)
  13. 山崎浩一,石坂彰敏,西村正治:気管支鏡下マイクロサンプリングを用いた気道上皮被覆液中の抗菌薬薬物動態の検討,臨床薬理の進歩2008,29: 54-63 (2008)
  14. 吉田貴之,南須原康行:Challenge QUIZ 貴方も名医,CLINIC magazine,462:36-37 72-73 (2008)
著書
  1. 南須原康行,西村正治:5. 疾患の評価 2 呼吸機能,COPDハンドブック,<中外医学社・桑平一郎 編>,30-40 (2008)
  2. 牧田比呂仁,西村正治:II 疾患の病因と病態 1. COPDの分類と病態,Annual Review 呼吸器 2008,<中外医学社・工藤翔二,土屋了介,金沢実,太田健 編>,63-69 (2008)