北海道大学病院内科Ⅰ(第一内科)

研究業績

業績

H22 研究業績

原著論文
  1. Konishi J,Yi F,Chen X,Vo H,Carbone DP,Dang TP.:“Notch3 cooperates with the EGFR pathway to modulate apoptosis through the induction of bim”,Oncogene,29(4):589-96(2010) PubMedへ
  2. Ichinose M,Seyama K,Nishimura M,Fukuchi Y,Nagai A,Mishima M,Kubo K;the Beta-2 Agonist Research and Evaluation Committee in COPD(BAREC) Study Group.:“Additive effects of transdermal tulobuterol to inhaled tiotropium in patients with COPD”,Respir Med,104(2):267-274(2010) PubMedへ
  3. Tanaka T,Matsuoka M,Sutani A,Gemma A,Maemondo M,Inoue A,Okinaga S,Nagashima M,Oizumi S,Uematsu K,Nagai Y,Moriyama G,Miyazawa H,Ikebuchi K,Morita S,Kobayashi K,Hagiwara K.:“Frequency of and variables associated with the EGFR mutation and its subtypes”,Int J Cancer,126(3):651-655(2010) PubMedへ
  4. Katayama M,Ishizaka A,Sakamoto M,Fujishima S,Sekiguchi K,Asano K,Betsuyaku T,Kotani T,Ware LB,Matthay MA,Hashimoto S.:“Laminin gamma2 fragments are increased in the circulation of patients with early phase acute lung injury”,Intensive Care Med,36(3):479-86(2010) PubMedへ
  5. Inoue A,Ishimoto O,Fukumoto S,Usui K,Suzuki T,Yokouchi H,Maemondo M,Kanbe M,Ogura S,Harada T,Oizumi S,Harada M,Sugawara S,Fukuhara T,Nukiwa T.:“A phase II study of amrubicin combined with carboplatin for elderly patients with small-cell lung cancer: North Japan Lung Cancer Study Group Trial 0405“,Ann Oncol,21 (4):800-803(2010) PubMedへ
  6. Mizugaki H,Shinagawa N,Kanegae K,Yamada N,Asahina H,Kikuchi E,Oizumi S,Tamaki N,Nishimura M.:“Combining transbronchial biopsy using endobronchial ultrasonography with a guide sheath and positron emission tomography for the diagnosis of small peripheral pulmonary lesions“,Lung Cancer,68(2):211-215(2010) PubMedへ
  7. Shigemura M,Nasuhara Y,Konno S,Hattori T,Shimizu C,Matsuno K,Nishimura M.:“Levels of Transferrin in Bronchoalveolar Lavage Fluid in Sarcoidosis”,Lung,188(2):151-157(2010) PubMedへ
  8. Ito K,Oizumi S,Fukumoto S,Harada M,Ishida T,Fujita Y,Harada T,Kojima T,Yokouchi H,Nishimura M;Hokkaido Lung Cancer Clinical Study Group.:“Clinical characteristics of pleomorphic carcinoma of the lung”,Lung Cancer, 68(2):204-10(2010) PubMedへ
  9. Moriyama C,Betsuyaku T,Ito Y,Hamamura I,Hata J,Takahashi H,Nasuhara Y,Nishimura M.:“Aging Enhances Susceptibility to Cigarette Smoke-Induced Inflammation through Bronchiolar Chemokines”,Am J Respir Cell Mol Biol,42(3):304-311(2010) PubMedへ
  10. Isada A,Konno S,Hizawa N,Tamari M,Hirota T,Harada M,Maeda Y,Hattori T,Takahashi A,Nishimura M.:“A functional polymorphism (-603A→G) in the tissue factor gene promoter is associated with adult-onset asthma”,J Hum Genet,55(3):167-174(2010) PubMedへ
  11. Fukutomi Y,Nakamura H,Kobayashi F,Taniguchi M,Konno S,Nishimura M,Kawagishi Y,Watanabe J,Komase Y,Akamatsu Y,Okada C,Tanimoto Y,Takahashi K,Kimura T,Eboshida A,Hirota R,Ikei J,Odajima H,Nakagawa T,Akasawa A,Akiyama K.:“Nationwide cross-sectional population-based study on the prevalences of asthma and asthma symptoms among Japanese adults”,Int Arch Allergy Immunol,153(3):280-287(2010) PubMedへ
  12. Gao PS,Shimizu K,Grant AV,Rafaels N,Zhou LF,Hudson SA,Konno S,Zimmermann N,Araujo MI,Ponte E,Cruz AA,Nishimura M,Su SN,Hizawa N,Beaty TH,Mathias RA,Rothenberg ME,Barnes KC,Bochner BS.:“Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma”,Eur J Hum Genet ,18(6):713-719(2010) PubMedへ
  13. 高橋 歩,今野 哲,伊佐田 朗,服部健史,清水薫子,清水健一,谷口菜津子,高橋大輔,谷口正実,赤澤 晃,檜澤伸之,西村正治:「気管支喘息及び鼻炎における血清総IgE値及び末梢血好酸球数の検討」,『アレルギー』,59(5):536-544(2010)
  14. Kikuchi J,Kinoshita I,Shimizu Y,Kikuchi E,Konishi J,Oizumi S,Kaga K,Matsuno Y, Nishimura M,Dosaka-Akita H.:“Distinctive expression of the polycomb group proteins Bmi1 polycomb ring finger oncogene and enhancer of zeste homolog 2 in nonsmall cell lung cancers and their clinical and clinicopathologic significance”,Cancer,116(12):3015-3024(2010) PubMedへ
  15. Maemondo M,Inoue A,Kobayashi K,Sugawara S,Oizumi S,Isobe H,Gemma A,Harada M,Yoshizawa H,Kinoshita I,Fujita Y,Okinaga S,Hirano H,Yoshimori K,Harada T,Ogura T,Ando M,Miyazawa H,Tanaka T,Saijo Y,Hagiwara K,Morita S,Nukiwa T; North-East Japan Study Group.:“Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR”,N Engl J Med,362(25):2380-2388(2010) PubMedへ
  16. Odajima N,Betsuyaku T,Yoshida T,Hosokawa T,Nishimura M.:“High levels of extracellular matrix metalloproteinase inducer are expressed in lymphangioleiomyomatosis”,Human Pathology,41(7):935-943(2010) PubMedへ
  17. Kobayashi M,Matsui K,Iwamoto Y,Ebi N,Oizumi S,Takeda K,Sawa T,Shibata K,Saka H,Imamura F,Seki N,Saito H,Goto I,Nakagawa K;West Japan Oncology Group.:“Phase II study of sequential triplet chemotherapy, irinotecan and cisplatin followed by amrubicin, in patients with extensive-stage small cell lung cancer: West Japan Thoracic Oncology Group Study 0301”,J Thorac Oncol,5(7):1075-1080(2010) PubMedへ
  18. Hattori T,Konno S,Takahashi A,Isada A,Shigemura M,Matsuno K,Shimizu C,Hizawa N,Yamaguchi E,Nishimura M.:“The role of atopy in the clinical course of pulmonary sarcoidosis in the Japanese population”,Allergy Asthma Proc,31(3):238-243(2010)
    )PubMedへ
  19. Shimohama T,Ako J,Yamasaki M,Otake H,Tsujino I,Hasegawa T,Nakatani D,Sakurai R,Chang H,Kusano H,Waseda K,Honda Y,Stone GW,Saito S, Fitzgerald PJ, Sudihr K.:“SPRIT III JAPAN versus SPRIT III USA A comparative intravascular ultrasound analysis of the everolimus-eluting stent”,Am J Cardiol,106(1):13-17(2010) PubMedへ
  20. Tazawa R,Transpell BC,Inoue Y,Arai T,Takada T,Nasuhara Y,Hizawa N,Kasahara Y,Tatsumi K,Hojo M,Ishii H,Yokoba M,Tanaka N,Yamaguchi E, Eda R, Tsuchihashi Y, MOrimoto K, Akira M, Terada M, Ohtsuka J, Ebina M, Kaneko C, Nukiwa T, Krischer JP, Akazawa K, Nakata K.:“Inhaled granulocyte/macrophage-colony stimulating factor as therapy for pulmonary alveolar proteinosis”,Am J Respir Crit Care Med,181(12):1345-1354(2010) PubMedへ
  21. 東山明日美,橋野 聡,小野澤真弘,高畑むつみ,岡田耕平,加畑 馨,谷口菜津子,南須原康行,久保田佳奈子,藤本 望,松野吉宏,西村正治,浅香正博:高度の肺野病変を呈した血管内大細胞型B細胞リンパ腫,血液臨床,51(5):353-356(2010)
  22. Yamada N,Oizumi S,Kikuchi E,Shinagawa N,Konishi-Sakakibara J,Ishimine A,Aoe K,Gemba K,Kishimoto T,Torigoe T,Nishimura M.:“CD8(+) tumor-infiltrating lymphocytes predict favorable prognosis in malignant pleural mesothelioma after resection”,Cancer Immunol Immunother,59(10):1543-1549(2010) PubMedへ
  23. Fukutomi Y,Nakamura H,Kobayashi F,Taniguchi M,Konno S,Nishimura M,Kawagishi Y,Watanabe J,Komase Y,Akamatsu Y,Okada C,Tanimoto Y,Takahashi K, Kimura T, Eboshiba A, Hirota R, Ikei J, Odajima H, Nakagawa T, Akasawa A, Akiyama K.:“Nationwaide cross-sectional population-based study on the prevalences of asthma and asthma symptoms among Japanese adults”,Int Arch Allergy Immunol,153(3):280-287(2010) PubMedへ
  24. Fujimoto N,Aoe K,Gemba K,Kato K,Yamazaki K,Kishimoto T.:“Clinical investigation of malignant mesothelioma in Japan”,J Cancer Res Clin Oncol,136(11):1755-1759(2010) PubMedへ
  25. Otake H,Ako J,Yamasaki M,Tsujino I,Shimohama T,Hasegawa T,Sakurai R,Waseda K,Honda Y,Sood P,Sudhir K,Stone GW,Fitzgerald PJ.:“Comparison of everolimus- versus paclitaxel-eluting stents implanted in patients with diabetes mellitus as evaluated by three-dimensional intravascular ultrasound analysis”,Am J Cardiol,106(4):492-497(2010) PubMedへ
  26. Deslee G,Adair Kirk TL,Betsuyaku T,Woods JC,Moore CH,Gierada DS,Conradi SH,Atkinson JJ,Toennies HM,Battaile JT,Kobayashi DK,Patterson GA,Holtzman MJ,Pierce RA.:“Cigarette smoke induces nucleic acid oxidation in lung fibroblasts”,Am J Respir Cell Mol Biol,43(5):576-584(2010) PubMedへ
  27. Shimizu K,Hasegawa M,Makita H,Nasuhara Y,Konno S,Nishimura M.:“Airflow limitation and airway dimensions assessed per bronchial generation in older asthmatics”,Respir Med,104:1809-1816(2010) PubMedへ
  28. Hattori T,Konno S,Takahashi A,Isada A,Shimizu K,Shimizu K,Taniguchi N,Gao P,Yamaguchi E,Hizawa N,Huang SK,Nishimura M.:“Genetic varians in mannose receptor gene (MRC1) confer susceptibility to increased risk of sarcoidosis”,BMC Medical Genetics,11:151-156(2010) PubMedへ
  29. Osawa R,Konno S,Akiyama M,Nemoto-Hasebe I,Nomura T,Nomura Y,Abe R,Sandilands A,McLean WH,Hizawa N,Nishimura M,Shimizu H.:“Japanese-Specific filaggrin gene mutations in Japanese patients suffering from atopic eczema and asthma”,J Invest Dermat,130:2834-2836(2010) PubMedへ
症例報告
  1. 吉田貴之,今野 哲,高橋 歩,南須原康行,別役智子,西村正治:「喘息として加療されフローボリューム曲線が発見の契機となった成人重複大動脈弓の1例」,『日本呼吸器学会雑誌』,48(3):229-234(2010)
  2. Konno S,Oizumi S,Shinagawa N,Kikuchi E,Konishi J,Ito K,Hizawa N,Takiyama A,Tanaka S,Nishimura M.:“Primary mediastinal liposarcoma, with 6 years of follow-up autopsy, revealed histopathological features of primary and metastatic lesions”,Inter Med,49:771-775(2010) PubMedへ
  3. Koiwa H,Tsujino I,Ohira H,Yoshinaga K,Otsuka N,Nishimura M.:“Imaging of cardiac sarcoid lesions using fasting cardiac 18F-fluorodeoxyglucose positron emission tomography : An autopsy case”,Circulation,122(5):535-536(2010) PubMedへ
  4. 清水薫子,今野 智,福家 聡,西浦洋一,西村正治:「急速に嚢胞性変化をきたした肺サルコイドーシスの1例」,『日本呼吸器学会雑誌』,48(9):715-718(2010)
  5. Maki K,Shinagawa N,Nasuhara Y,Oizumi S,Domen H,Haga H,Nishimura M.:“Endobronchial actinomycosis associated with a foreign body - successful short-term treatment with antibiotics-”,Intern Med,49(13):1293-1296(2010) PubMedへ
  6. 谷口菜津子,大泉聡史,原田敏之,服部淳夫,松野吉宏,西村正治:「著名な石灰化を伴うリンパ節腫大で再発した肺腺癌の1例」,『肺癌』,50(6):816-821(2010)
  7. Shimizu K,Konno S,Nasuhara Y,Tanino M,Matsuno Y,Nishimura M.:“A case of follicular bronshiolitis associated with asthma eosinophilia and increased immunoglobulin E”,Journal of Asthma,47(10):1161-1164(2010) PubMedへ
  8. Ito N,Tsujino I,Nishimura M.:“Enhanced computed tomography unveiling the underlying couse of pulmonary hypertension”,Int J Cardiovasc Imaging,26(3):257-258(2010) PubMedへ
  9. Sato T,Kanzaki H,Ishida Y,Amaki M,Ohara T,Hasegawa T,Hashimura K,Nakatani S,Yamada N,Ikeda Y,Ueda-Ishibashi H,Kitakaze M.:“Second left ventricular aneurysm newly developed in a patient with untreated cardiac sarcoidosis”,Circulation Journal,74(11):2477-2478(2010) PubMedへ
総説・解説
  1. 西村正治:「第37回箱根呼吸討論会記録 印象記」,『呼吸』,29(1):74-75(2010)
  2. 別役智子:「第37回箱根呼吸討論会記録No.2COPDの病態における炎症と酸化ストレス」,『呼吸』,29(1):89-102(2010)
  3. 長井 桂,西村正治:「特集COPDの診療updateCOPD発症のプロセス」,『日本医師会雑誌』,138(12):2473-2477(2010)
  4. 別役智子:「特集COPDの診療updateCOPDの分子メカニズム」,『日本医師会雑誌』,138(12):2510(2010)
  5. 山下直美,永井厚志,國近尚美,駒瀬裕子,近藤光子,別役智子:「座談会 呼吸器診療における女性医師への期待と今後の展望」,『レスピレーションリサーチファンデーション』,29(3):233-242(2010)
  6. 福地義之助,西村正治,巽 浩一郎,橋本 修:「座談会 末梢気道閉塞へのアプローチ -COPD薬物療法の新視点-」,『アボット』1-7(2010)
  7. 今野 哲,西村正治:「シリーズ:考えてみよう 臨床クイズ 側胸部痛を主訴に受診し、前肺野に多発する嚢胞性病変を認めた症例」,『日本内科学会雑誌』,99(5):190,216-217(2010)
  8. Otake H,Honda Y,Yamasaki M,Tsujino I,Shimohama T,Sakurai R,Hasegawa T,Waseda K,Ako J,Fitzgerald PJ.:“Vascular response to overlapping everolimus-eluting stents-comparison with paclitaxel-eluting stents-”,Circ J,74(5):1023-1025(2010) PubMedへ
  9. Koo BK,Waseda K,Ako J,Hasegawa T,Shimohama T,Nakatani D,Otake H,Yamasaki M,Sakurai R,Tsujino I,Honda Y,Fitzgerald PJ.:“Incidence of diffuse and focal chronic stent recoil after implantation of current generation bare-metal and drug-eluting stents”,Int J Cardiol,144(1):132-134(2010) PubMedへ
  10. 別役智子,:「第80回閉塞性肺疾患研究会 Laser capture microdissection (LCM) を用いた細胞特異的遺伝子発現解析-COPDの病態への応用-(基礎・臨床)」,『呼吸』,29(7):748-750(2010)
  11. 大泉聡史,品川尚文:「肺癌・セミナー/肺癌診療の最新知識とその活用 気管支鏡による新たな診断主義-超音波内視鏡-」,『Medical Practice』,27(7):1127-1131(2010)
  12. 福家 聡,西村正治:「今月の主題 呼吸不全の診療 呼吸不全を招く疾患 COPD:慢性閉塞性肺疾患」,『medicina』,47(8):1424-1427(2010)
  13. 福家 聡,西村正治:「特集 外来診療の極意-慢性呼吸器疾患 COPDの外来診療」,『呼吸器内科』,18(2):94-100(2010)
  14. 南 信明,松崎正一,望月紘一,永井厚志,西村正治,三島理晃:「慢性呼吸器疾患(喘息・COPD)に関する診療の実態調査 2008」,『日本臨床内科医会会誌』,25(1):96-104(2010)
  15. 福地義之助,一ノ瀬正和,相澤久道,西村正治:「座談会 UPLIFT 日本集団の解析結果の真価を問う」,『Medical Tribune』,2010年11月11日号
  16. 清水薫子,西村正治:「末梢軌道病変へのアプローチ 3)画像的アプローチ」,『呼吸器内科』,18(3):262-265(2010)
著書
  1. 西村正治:「気管支拡張症」,『今日の診断指針 第6版』,【医学書院・東京・金澤一郎,永井良三編】,957-958(2010)

  2. 品川尚文:「Ⅲ.診断の進歩 9.バーチャル気管支鏡ナビゲーション」,『Annual Review 呼吸器2010』,【中外医学社・東京・永井厚志,巽 浩一郎, 桑野和善, 高橋和久編】,179-185(2010)

学会賞
  1. 今野 哲,牧田比呂仁,南須原康行,別役智子,西村正治:COPD患者の気管支拡張反応に与えるアドレナリン受容体遺伝子(ADRB2)多型の意義,第19回Pneumo Forum賞
  2. Konno S,Makita H,Hasegawa M,Shimizu K,Nasuhara Y,Betsuyaku T,Nishimura M:Association of beta2-adrenoreceptor genotype with bronchodilator responses (BDR) in COPD,日本呼吸器学会International Session Award 2010
  3. 長谷川 大:Assessment of the normal human lung via dual energy multi-detector computed tomography and its application in phenotyping asthma and COPD,第10回日本呼吸器疾患研究基金ファイザーフェローシップ
  4. 清水薫子:臨床安定期の中・高年気管支喘息患者における肺CT3次元気道解析でみた気道病変と気流閉塞との関係,第2回呼吸機能イメージング研究会優秀演題賞